Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 18 Researches
8.1
USERS' SCORE
Good
Based on 18 Reviews
8.1
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B6 (as Pyridoxal-5-Phosphate)
1.5 mg
88%
Folate (400 mcg as (6S)-5-MTHF [from (6S)-5-Methyltetrahydrofolate Glucosamine Salt])
680 mcg DFE‡
170%
Vitamin B12 (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
9
Niacin reduces cholesterol and oxidative stress
We examined how niacin (vitamin B3) impacts cholesterol levels and oxidative stress in patients with low HDL cholesterol. In this study, 17 participants with high cholesterol received niacin treatment over 12 weeks, while 8 healthy individuals served as controls.
The results were promising. We discovered a significant boost in HDL cholesterol and a drop in triglycerides among the patients. More importantly, niacin also reduced markers of oxidative stress, suggesting its benefits extend beyond just cholesterol management. However, CRP levels remained unchanged.
The results were promising. We discovered a significant boost in HDL cholesterol and a drop in triglycerides among the patients. More importantly, niacin also reduced markers of oxidative stress, suggesting its benefits extend beyond just cholesterol management. However, CRP levels remained unchanged.
Read More
9
Vitamin B6 reduces cholesterol levels
We aimed to understand how Vitamin B6 influences high cholesterol levels, particularly through its effects on lipid metabolism in rats induced by a high-fat diet. To set the stage for our exploration, we used male Sprague-Dawley rats and placed them on this fat-rich diet for two weeks to establish a hyperlipidemia model.
We then supplied two groups of rats with varying doses of Vitamin B6—2.00 mg/kg and 3.00 mg/kg daily over the next eight weeks. Our findings shed light on Vitamin B6's potential to lower harmful Low-Density Lipoprotein Cholesterol (LDL-C) and overall blood cholesterol levels.
What's more, we observed significant reductions in triglycerides, atherogenic indexes, and various lipid ratios, while beneficial High-Density Lipoprotein Cholesterol (HDL-C) levels were elevated. The supplementation helped reduce fat accumulation in the liver and restored more normal heart and body weight ratios, highlighting its possible protective role against fat-related conditions.
Overall, our study suggests that Vitamin B6 could play an essential role in combating dyslipidemia and promoting better liver health through various mechanisms. These findings provide promising insights into a nutritional approach to managing high cholesterol and emphasize the importance of diet in health management.
We then supplied two groups of rats with varying doses of Vitamin B6—2.00 mg/kg and 3.00 mg/kg daily over the next eight weeks. Our findings shed light on Vitamin B6's potential to lower harmful Low-Density Lipoprotein Cholesterol (LDL-C) and overall blood cholesterol levels.
What's more, we observed significant reductions in triglycerides, atherogenic indexes, and various lipid ratios, while beneficial High-Density Lipoprotein Cholesterol (HDL-C) levels were elevated. The supplementation helped reduce fat accumulation in the liver and restored more normal heart and body weight ratios, highlighting its possible protective role against fat-related conditions.
Overall, our study suggests that Vitamin B6 could play an essential role in combating dyslipidemia and promoting better liver health through various mechanisms. These findings provide promising insights into a nutritional approach to managing high cholesterol and emphasize the importance of diet in health management.
Read More
8
We explored how N(1)-methylnicotinamide (MNA+) can improve blood vessel relaxation, particularly in those with high cholesterol. The study involved both healthy and hypercholesterolemic participants taking MNA+ and demonstrated significant improvements in flow-mediated dilation, which is linked to enhanced nitric oxide (NO) production.
This increase in NO bioavailability indicates that MNA+ could play a helpful role in managing conditions like hypercholesterolemia. Overall, our findings suggest MNA+ may be a promising avenue for addressing endothelial issues related to high cholesterol.
This increase in NO bioavailability indicates that MNA+ could play a helpful role in managing conditions like hypercholesterolemia. Overall, our findings suggest MNA+ may be a promising avenue for addressing endothelial issues related to high cholesterol.
Read More
Most Useful Reviews
9
Effective for health
238 people found this helpful
A very good, effective product. It combines Methylfolate and B12 in active forms, and the taste is pleasant. It enhances absorption and assists with high cholesterol and anaemia. I have noticed improvements in my overall wellbeing and mood.
Read More
9
Boosted mood
105 people found this helpful
I initially overlooked this product but was thrilled upon discovering its active ingredients. I previously ordered folic acid and B12 separately, but now I get both together and sublingually. These tablets have positively impacted my mood within half an hour after taking them.
Read More
9
Controlled homocysteine
59 people found this helpful
I previously ordered a higher-priced version of this complex to lower my high cholesterol. After taking it consistently, my homocysteine levels dropped significantly, which I am very pleased with.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 18 Researches
8.1
- All Researches
9
We explored the effectiveness of a dietary supplement combining red yeast rice and other natural compounds for lowering cholesterol in children with high cholesterol.
In a study involving 84 children and adolescents, the supplement significantly decreased total cholesterol and harmful LDL cholesterol after 6 and 16 months. However, there were no notable changes in HDL cholesterol or triglycerides.
Interestingly, those who had been taking phytosterols saw even better results after starting the supplement. Overall, this treatment appears safe and effective, but more research is needed to confirm these findings in larger groups.
In a study involving 84 children and adolescents, the supplement significantly decreased total cholesterol and harmful LDL cholesterol after 6 and 16 months. However, there were no notable changes in HDL cholesterol or triglycerides.
Interestingly, those who had been taking phytosterols saw even better results after starting the supplement. Overall, this treatment appears safe and effective, but more research is needed to confirm these findings in larger groups.
Read More
9
We aimed to understand how plasma niacin, an important B vitamin, relates to high cholesterol levels, particularly in individuals with diabetes. In our study involving 2,647 participants, we found that higher levels of plasma niacin were linked to a significantly lower risk of hyperlipidemia in those with diabetes.
This connection didn’t hold true for nondiabetic participants. Interestingly, our results showed consistent benefits across various subgroups, indicating that niacin might play a promising role in cholesterol management for diabetic patients, though more research is necessary for those without diabetes.
This connection didn’t hold true for nondiabetic participants. Interestingly, our results showed consistent benefits across various subgroups, indicating that niacin might play a promising role in cholesterol management for diabetic patients, though more research is necessary for those without diabetes.
Read More
9
We aimed to explore whether a low daily dose of monacolin K from red yeast rice (RYR) could help lower cholesterol levels. In a well-designed, randomized, double-blind, placebo-controlled study, 142 participants with high cholesterol took either RYR or a placebo for 12 weeks.
Participants taking RYR saw a significant drop in low-density lipoprotein cholesterol (LDL-C) by 14.8% and total cholesterol by 11.2%. Impressively, over half reached the recommended LDL-C levels. However, those who received the placebo showed no notable changes.
This study suggests that a small daily dose of monacolin K can be effective in helping manage cholesterol levels.
Participants taking RYR saw a significant drop in low-density lipoprotein cholesterol (LDL-C) by 14.8% and total cholesterol by 11.2%. Impressively, over half reached the recommended LDL-C levels. However, those who received the placebo showed no notable changes.
This study suggests that a small daily dose of monacolin K can be effective in helping manage cholesterol levels.
Read More
9
We examined the effectiveness of nutraceuticals in lowering cholesterol levels and blood pressure for patients with high cholesterol and hypertension. Over six months, 66 participants took a daily tablet containing red yeast rice, policosanol, berberine, folic acid, and coenzyme Q10 alongside usual diet management.
The results showed significant reductions in total cholesterol and LDL cholesterol, while HDL levels remained unchanged. Importantly, no improvements were observed in the control group. Overall, these nutraceuticals appear safe and effective for enhancing lipid profiles in this specific patient group.
The results showed significant reductions in total cholesterol and LDL cholesterol, while HDL levels remained unchanged. Importantly, no improvements were observed in the control group. Overall, these nutraceuticals appear safe and effective for enhancing lipid profiles in this specific patient group.
Read More
9
Niacin reduces cholesterol and oxidative stress
We examined how niacin (vitamin B3) impacts cholesterol levels and oxidative stress in patients with low HDL cholesterol. In this study, 17 participants with high cholesterol received niacin treatment over 12 weeks, while 8 healthy individuals served as controls.
The results were promising. We discovered a significant boost in HDL cholesterol and a drop in triglycerides among the patients. More importantly, niacin also reduced markers of oxidative stress, suggesting its benefits extend beyond just cholesterol management. However, CRP levels remained unchanged.
The results were promising. We discovered a significant boost in HDL cholesterol and a drop in triglycerides among the patients. More importantly, niacin also reduced markers of oxidative stress, suggesting its benefits extend beyond just cholesterol management. However, CRP levels remained unchanged.
Read More
User Reviews
USERS' SCORE
Good
Based on 18 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective for health
238 people found this helpful
A very good, effective product. It combines Methylfolate and B12 in active forms, and the taste is pleasant. It enhances absorption and assists with high cholesterol and anaemia. I have noticed improvements in my overall wellbeing and mood.
Read More
9
Boosted mood
105 people found this helpful
I initially overlooked this product but was thrilled upon discovering its active ingredients. I previously ordered folic acid and B12 separately, but now I get both together and sublingually. These tablets have positively impacted my mood within half an hour after taking them.
Read More
9
Controlled homocysteine
59 people found this helpful
I previously ordered a higher-priced version of this complex to lower my high cholesterol. After taking it consistently, my homocysteine levels dropped significantly, which I am very pleased with.
Read More
9
Effective supplement
14 people found this helpful
This is an excellent supplement for lowering high cholesterol levels, which significantly reduces the risk of serious cardiovascular diseases. I highly recommend it!
Read More
9
Cholesterol improvement
2 people found this helpful
I have been taking this supplement again due to previous high cholesterol readings. Along with lifestyle changes, it has successfully normalised my cholesterol levels for the first time in seven years. I am thrilled with the outcome.
Read More
Frequently Asked Questions
9
Cholesterol improvement
2 people found this helpful
I have been taking this supplement again due to previous high cholesterol readings. Along with lifestyle changes, it has successfully normalised my cholesterol levels for the first time in seven years. I am thrilled with the outcome.
9
Normalised levels
2 people found this helpful
Homocysteine normalised after taking this for a month. The dosage of B12 and methyl folate is substantial in this supplement. I began with 1/6 of a pill and gradually increased to 2 per day.
9
Boosted mood
105 people found this helpful
I initially overlooked this product but was thrilled upon discovering its active ingredients. I previously ordered folic acid and B12 separately, but now I get both together and sublingually. These tablets have positively impacted my mood within half an hour after taking them.
9
Effective improvement
2 people found this helpful
I purchased this to reduce my high cholesterol levels, and after four months, my homocysteine decreased from 16 to 8. The quality is excellent, and I enjoyed the taste.
7.5
Energy boost
An excellent combination of B vitamins improved my energy levels and helped with my high cholesterol due to its superior ingredients. I highly recommend it.
9
Cholesterol normalisation
1 people found this helpful
This helps to reduce high cholesterol when taken with Jarrow TMG, returning homocysteine to normal in two months. Take one tablet an hour after a meal.
7.5
Maintained blood counts
26 people found this helpful
My husband, who has type 2 diabetes, takes this supplement to counter the decrease in vitamin B12 caused by his medication. He's been taking it regularly for three months, and both his blood counts and high cholesterol levels have stabilised.
9
Improved cholesterol levels
241 people found this helpful
Superb! I take it periodically to address my high cholesterol and correct anaemia. This supplement is highly effective. Following its use, my lipid profile improved significantly, and my tests indicated a reduction in cholesterol levels. Exercises and diet modifications helped, but the supplement produced even better results.
9
We explored the effectiveness of a dietary supplement combining red yeast rice and other natural compounds for lowering cholesterol in children with high cholesterol.
In a study involving 84 children and adolescents, the supplement significantly decreased total cholesterol and harmful LDL cholesterol after 6 and 16 months. However, there were no notable changes in HDL cholesterol or triglycerides.
Interestingly, those who had been taking phytosterols saw even better results after starting the supplement. Overall, this treatment appears safe and effective, but more research is needed to confirm these findings in larger groups.
In a study involving 84 children and adolescents, the supplement significantly decreased total cholesterol and harmful LDL cholesterol after 6 and 16 months. However, there were no notable changes in HDL cholesterol or triglycerides.
Interestingly, those who had been taking phytosterols saw even better results after starting the supplement. Overall, this treatment appears safe and effective, but more research is needed to confirm these findings in larger groups.
9
We aimed to explore whether a low daily dose of monacolin K from red yeast rice (RYR) could help lower cholesterol levels. In a well-designed, randomized, double-blind, placebo-controlled study, 142 participants with high cholesterol took either RYR or a placebo for 12 weeks.
Participants taking RYR saw a significant drop in low-density lipoprotein cholesterol (LDL-C) by 14.8% and total cholesterol by 11.2%. Impressively, over half reached the recommended LDL-C levels. However, those who received the placebo showed no notable changes.
This study suggests that a small daily dose of monacolin K can be effective in helping manage cholesterol levels.
Participants taking RYR saw a significant drop in low-density lipoprotein cholesterol (LDL-C) by 14.8% and total cholesterol by 11.2%. Impressively, over half reached the recommended LDL-C levels. However, those who received the placebo showed no notable changes.
This study suggests that a small daily dose of monacolin K can be effective in helping manage cholesterol levels.
9
We aimed to understand how plasma niacin, an important B vitamin, relates to high cholesterol levels, particularly in individuals with diabetes. In our study involving 2,647 participants, we found that higher levels of plasma niacin were linked to a significantly lower risk of hyperlipidemia in those with diabetes.
This connection didn’t hold true for nondiabetic participants. Interestingly, our results showed consistent benefits across various subgroups, indicating that niacin might play a promising role in cholesterol management for diabetic patients, though more research is necessary for those without diabetes.
This connection didn’t hold true for nondiabetic participants. Interestingly, our results showed consistent benefits across various subgroups, indicating that niacin might play a promising role in cholesterol management for diabetic patients, though more research is necessary for those without diabetes.
8
Novel compounds lower cholesterol levels
We evaluated the antihyperlipidemic effects of new compounds derived from nicotinic acid in rats fed a high-cholesterol diet.
Our findings revealed that these compounds, specifically 6e and 6f, significantly lowered total cholesterol levels by 14-19%, triglycerides by 24-28%, and LDL cholesterol by 16%.
Notably, they also boosted HDL cholesterol by 33-41%. This research suggests that these novel compounds could be beneficial for managing cholesterol levels, similar to existing treatments.
Our findings revealed that these compounds, specifically 6e and 6f, significantly lowered total cholesterol levels by 14-19%, triglycerides by 24-28%, and LDL cholesterol by 16%.
Notably, they also boosted HDL cholesterol by 33-41%. This research suggests that these novel compounds could be beneficial for managing cholesterol levels, similar to existing treatments.
References
- Garoufi A, Papadaki M, Kalogiannis M, Zerva U, Charakida M, et al. Beneficial Effects of a Nutraceutical Combination on Lipid Profiles in Children with Moderate and Severe Hypercholesterolemia. Biomolecules. 2024;14. 10.3390/biom14121608
- Geng X, Lin Z, Zheng Z, Lin Q, Sun T, et al. Plasma niacin is inversely associated with hyperlipidemia in participants with diabetes among Chinese adults. Nutr Res. 2024;131:54. 10.1016/j.nutres.2024.09.006
- Shoman ME, Aboelez MO, Shaykhon MSA, Ahmed SA, Abuo-Rahma GEA, et al. New nicotinic acid-based 3,5-diphenylpyrazoles: design, synthesis and antihyperlipidemic activity with potential NPC1L1 inhibitory activity. Mol Divers. 2021;25:673. 10.1007/s11030-020-10039-9
- Heinz T, Schuchardt JP, Möller K, Hadji P, Hahn A. Low daily dose of 3 mg monacolin K from RYR reduces the concentration of LDL-C in a randomized, placebo-controlled intervention. Nutr Res. 2016;36:1162. 10.1016/j.nutres.2016.07.005
- Qin X, Li J, Spence JD, Zhang Y, Li Y, et al. Folic Acid Therapy Reduces the First Stroke Risk Associated With Hypercholesterolemia Among Hypertensive Patients. Stroke. 2016;47:2805.
- Mazza A, Lenti S, Schiavon L, Zuin M, D'Avino M, et al. Nutraceuticals for Serum Lipid and Blood Pressure Control in Hypertensive and Hypercholesterolemic Subjects at Low Cardiovascular Risk. Adv Ther. 2015;32:680. 10.1007/s12325-015-0229-x
- Garaiova I, Muchová J, Nagyová Z, Mišľanová C, Oravec S, et al. Effect of a plant sterol, fish oil and B vitamin combination on cardiovascular risk factors in hypercholesterolemic children and adolescents: a pilot study. Nutr J. 2013;12:7. 10.1186/1475-2891-12-7
- Hamoud S, Kaplan M, Meilin E, Hassan A, Torgovicky R, et al. Niacin administration significantly reduces oxidative stress in patients with hypercholesterolemia and low levels of high-density lipoprotein cholesterol. Am J Med Sci. 2013;345:195. 10.1097/MAJ.0b013e3182548c28
- Domagala TB, Szeffler A, Dobrucki LW, Dropinski J, Polanski S, et al. Nitric oxide production and endothelium-dependent vasorelaxation ameliorated by N1-methylnicotinamide in human blood vessels. Hypertension. 2012;59:825. 10.1161/HYPERTENSIONAHA.111.183210
- Marazzi G, Cacciotti L, Pelliccia F, Iaia L, Volterrani M, et al. Long-term effects of nutraceuticals (berberine, red yeast rice, policosanol) in elderly hypercholesterolemic patients. Adv Ther. 2011;28:1105. 10.1007/s12325-011-0082-5
- Zhang RY, Chen Y, Yan XQ, Zhang Y, Zhou H, et al. Association of pyridoxal 5'-phosphate (PLP) with lipid profiles: a population-based cohort study. Front Nutr. 2025;12:1545301. 10.3389/fnut.2025.1545301
- Xie RP, Liang XF, Peng D, Zhang QW, Wu DL, et al. Dietary supplementation of pyridoxine can enhance the growth performance and improve the protein, lipid utilization efficiency of mandarin fish (Siniperca chuatsi). Fish Physiol Biochem. 2023;49:1063. 10.1007/s10695-023-01223-3
- Abbas Torki S, Bahadori E, Shekari S, Fathi S, Gholamalizadeh M, et al. Association between the index of nutritional quality and lipid profile in adult women. Endocrinol Diabetes Metab. 2022;5:e358. 10.1002/edm2.358
- Haidari F, Mohammadshahi M, Zarei M, Haghighizadeh MH, Mirzaee F. The Effect of Pyridoxine Hydrochloride Supplementation on Leptin, Adiponectin, Glycemic Indices, and Anthropometric Indices in Obese and Overweight Women. Clin Nutr Res. 2021;10:230. 10.7762/cnr.2021.10.3.230
- Zhang Q, Zhang DL, Zhou XL, Li Q, He N, et al. Antihyperlipidemic and Hepatoprotective Properties of Vitamin B6 Supplementation in Rats with High-Fat Diet-Induced Hyperlipidemia. Endocr Metab Immune Disord Drug Targets. 2021;21:2260. 10.2174/1871530321666210809152555
- Shabbir M, Afsar T, Razak S, Almajwal A, Khan MR. Phytochemical analysis and Evaluation of hepatoprotective effect of Maytenus royleanus leaves extract against anti-tuberculosis drug induced liver injury in mice. Lipids Health Dis. 2020;19:46. 10.1186/s12944-020-01231-9
- Li J, Yin L, Wang L, Li J, Huang P, et al. Effects of vitamin B6 on growth, diarrhea rate, intestinal morphology, function, and inflammatory factors expression in a high-protein diet fed to weaned piglets1. J Anim Sci. 2019;97:4865. 10.1093/jas/skz338
- Qi J, Wu H, Chen H, Han W. Genetically predicted lipid traits mediate the association between folic acid and atherosclerosis. Sci Rep. 2024;14:19052. 10.1038/s41598-024-69728-2
